THE RELATIONSHIP BETWEEN SERUM MAGNESIUM, CALCIUM, AND PARATHYROID HORMONE IN HYPERPARATHYROID PATIENTS: A CASE-CONTROL ANALYSIS
Meghaa Venkateshwaran1, Mamta Singh1, Praveen Kumar1, Ben Ashok1,2, Rahul Abishake1
1Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai – 600116, India
2NURA – Ai Health Screening Center, Bengaluru – 560038, India
ABSTRACT: Hyperparathyroidism is an endocrine disorder characterized by elevated parathyroid hormone (PTH) levels. This study investigated the correlation between serum magnesium, calcium, and PTH levels in hyperparathyroid patients. Methods A case-control study was conducted with 81 hyperparathyroid patients and 81 healthy controls. Our current study was conducted at a tertiary care health center in Chennai, Tamil Nadu. Serum magnesium, calcium, and PTH levels were measured in both cases and controls. Statistical analysis was performed using SPSS version 23.0, including t-tests and Pearson’s correlation. Results: Hyperparathyroid patients showed significantly lower serum magnesium levels (1.8±0.3 mg/dL) compared to controls (1.9±0.4 mg/dL, p=0.004). PTH levels were significantly higher in cases (278±311.8 pg/dL) than controls (42.2±11.1 pg/dL, p<0.001). No significant correlation was found between serum magnesium and PTH levels (r=-0.121, p=0.122). A weak positive correlation was observed between serum magnesium and calcium levels (r=0.120, p=0.876), while a negative correlation was found between serum calcium and PTH levels (r=-0.122, p=0.120). Conclusion: This study revealed a complex relationship between serum magnesium, calcium, and PTH in hyperparathyroidism. While PTH levels were elevated in hyperparathyroid patients, the relationship between serum magnesium and PTH was not directly correlated, suggesting that the relationship between these parameters appears complex and needs further investigation.
KEYWORDS: Cardiovascular Health, Renal Function, Bone Health, Endocrine Disorders, Biochemical Parameters, Parathyroid Hormone (PTH), Calcium Levels, Serum Magnesium, Hyperparathyroidism