LIPID-BASED NANOCARRIERS FOR ORAL DELIVERY OF POORLY WATER-SOLUBLE DRUGS: A COMPREHENSIVE REVIEW ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS)
Prashant Thapliyal1, Sumit Khanduri2, Yusra Ahmad3
1Research Scholar, 2Assistant Professor, 3H.O.D.,
Faculty of Pharmacy, Veer Madho Singh Bhandari Uttrakhand Technical University
Dehradun, Uttrakhand, India
Abstract: Oral drug delivery is predominantly limited by the low aqueous solubility that leads to low dissolution rate and hence poor bioavailability. Lipid-based nanocarriers provide a logical answer to this challenges as they enhance solubilization, prevent drug degradation and escalate intestinal absorption. The classification, mechanisms, formulation techniques, and advantages and limitations of the major lipid-based systems (i.e., SLNs, NLCs, liposomes, niosomes SEDDSs and SNEDDS) are presented in this study. Especially self-nanoemulsifying systems are focussed because of its success in poorly water-soluble drugs. Comparative aspects of vesicular and non-vesicular systems are also highlighted. Solid SNEDDS and lipid-polymer hybrid nanocarriers are examples of future developments that have the potential to improve stability and performance. In general, lipid-based nanocarriers show promise as a means of improving oral bioavailability.
Keywords: Lipid-based nanocarriers; Solid lipid nanoparticles (SLN); Nanostructured lipid carriers (NLC); Self-nanoemulsifying drug delivery systems (SNEDDS); Poorly water-soluble drugs; Oral bioavailability; Hybrid nanocarriers.
VOLUME 10 ISSUE 04 2026: 118 – 142