IN-SITU GELS: A DETAILED OVERVIEW
Anubhav Pant, Pragati Bailwal, Yusra Ahmad
Faculty of Pharmacy, Veer Madho Singh Bhandari Uttarakhand Technical University,
Dehradun, Uttrakhand, India
Abstract: Background-In-situ gels have been providing a promising approach due to its sustained and controlled delivery of drug offering an incrementation in patient compliances due to target site specific release and reduction in dose frequency, as transition occurs in solution to gel under exposure of physiological condition depending on type of polymer used like temperature, pH, ionic providing a larger target section of diseases on ophthalmic, nasal, vaginal, oral. Aim- The review below aimed benefits of in-situ gel over conventional formulation with the current marketed formulation present. Method- In-situ gel formulation is dependent on the type of polymer used for specific purpose like thermo-responsive, ion-activated, pH-sensitive and the evaluation parameter depending on the methods and the targeted disease pH, gelation time, capacity, viscosity, in-vitro gelation studies using simulated physiological fluid (STF), rheological studies. Future advancement-.In-situ gel have been prepared by 3D printing a recent advancement in hybrid approach allowing the development of bio-links its advantages and application are clearly visible in field of tissue engineering, patient specific implant, wound healing, controlled drug delivery providing a localized therapeutic delivery ,showing a recent advancement in personalized medicine, and polymer science, causing development in stimuli-responsive gel having enhancement in biocompatibility, mechanical strength and drug loading efficiency hence this review below provides an comprehensive overview of different types of in-situ with formulation and mechanism diseases that can be targeted, evaluation parameters with recent and future advancement in-situ gel in personalized medicines. Conclusion- In-situ gel shows a modern and enhanced approach to drug delivery as compared to traditional/conventional formulation
Keywords- In-situ gels, thermos-responsive, ion-activated, pH sensitive, evaluation, 3D printing, nano delivery.
VOLUME 10 ISSUE 03 2026: 30 – 53