GASTRORETENTIVE DRUG DELIVERY SYSTEMS: A MODERN INSIGHTS ON APPROACHES AND APPLICATIONS
Patel Rozinaparvin Iqbal1, Dr. Chainesh Shah2, Dr. Nidhi Chauhan3, Dr. Umesh Upadhyay4
1Ph. D Research Scholar, 2Research Supervisor, Research Coordinator & Professor, 4Dean,Faculty of Pharmacy, Sigma University, Vadodara – 390019, India
3Research Co-supervisor & Professor, Laxminarayandev College of Pharmacy, Bharuch – 392001, India
ABSTRACT: The pharmaceutical research sector is very interested in oral gastro-retentive dose formulations. The importance of gastro-retentive drug delivery systems (GRDDS) was boosted by these systems, which also improved patient compliance with higher medication therapeutic indices. The use of different technical advancements in the design and production of gastroretentive dosage forms can alleviate a number of physiological restrictions associated with these forms, such as short gastric retentive time and fluctuations in stomach emptying time. Medication having shorter half-lives, unstable or poorly soluble at alkaline pH, or poor absorption in the lower gastrointestinal tract can benefit greatly from GRDDS. In order to achieve the required retention period and release pattern, the system may be built using a range of innovative methods, including magnetic, bioadhesive, expandable, and floating systems. The use of gastro-retentive drug delivery systems (GRDDS) for the oral administration of medications has significantly increased in recent years. A number of innovative design strategies, including the widely used floating drug delivery system (FDDS), have been used to create effective GRDDS. GRDDS has a number of advantages, including the capacity to provide drugs with a narrow window for absorption, improve pharmacological effects, lower dose frequency, increase bioavailability, and extend the duration of the drug’s residency in the stomach for local effects like the treatment of peptic ulcer disease. The purpose of this study is to give a brief introduction to gastro retentive drug delivery (GRDD), including its need, advantages, disadvantages, factors affecting, approach and also its applications.
KEYWORDS: Gastroretentive, GRDDS, bioadhesive, bioavailability, gastrointestinal tract, floating drug delivery system.