A BRIFE REVIEW ON CUBOSOMES: STRUCTURAL INFORMATION, METHOD OF PREPARATION EVALUATION AND RECENT APPLICATION
Prajapati Rahul Vinitbhai1*, Dr. Chainesh N. Shah2, Dr. Umesh Upadhyay3
1Ph. D Scholar, 2Research Coordinator & Professor, 3Dean & Professor,Faculty of Pharmacy, Sigma University, Bakrol, Vadodara – 390019
ABSTRACT: Cubosomes are particles that are square or spherical and have visible cubic lattices inside. The fascinating story of how the cubosome was discovered involves differential geometry, biological membranes, digestion, and food science. Cubosomes are thermodynamically stable and have a structure that looks like honeycomb. Amphiphilic lipids are the building blocks of cubosomes, which are joined by a polymer. Cubosomes can be utilized to treat skin, hair, and other substantial tissues in various ways, including parenteral, oral, mucosal, and transdermal. Polymers can be utilized to target the outer circle, and cubosome formation can be manipulated to design pore size or include bioactive lipids. Additionally, they are quite secure in physiological conditions. Due to their network topology, they can catch more drugs. Cubosomes are liquid crystalline nanoparticles with a unique internal cubic structure and content that self-assemble. Cubosomes are made by dispersing a solid-like phase into smaller particles after hydrating a surfactant or polar lipid into a cubic phase. They have strong like rheology with one-of-a-kind elements that are valuable practically speaking. Cubosomes can contain molecules that are hydrophobic, hydrophilic, or amphiphilic. Cubosomes can make drugs that are hard to dissolve more soluble. Treatment of skin, hair, and other body tissues with cubosome-like vehicle activity of biological substances and controlled release of solubilized chemicals are examples of cubosome applications. Melanoma (malignant growth) treatment in view of a size conveyance framework is the way to successfully focusing on melanoma because of expanded porousness and maintenance.
KEY WORDS: Cubosomes, Drug-loading hydrophilic, Hydrophobic, Amphiphilic, Lyotropic liquid crystals, Biocontinuous, Nanoparticles, Honeycomb